Rapid Responsiveness to Practice Predicts Longer-Term Retention of Upper Extremity Motor Skill in Non-Demented Older Adults

Skill acquisition is a form of motor learning that may provide key insights into the aging brain. Although previous work suggests that older adults learn novel motor tasks slower and to a lesser extent than younger adults, we have recently demonstrated no significant effect of chronological age on the rates and amounts of skill acquisition, nor on its longterm retention, in adults over the age of 65. To better understand predictors of skill acquisition in non-demented older adults, we now explore the relationship between early improvements in motor performance due to practice (i.e., rapid responsiveness) and longer-term retention of an upper extremity motor skill, and whether the extent of rapid responsiveness was associated with global cognitive status. Results showed significant improvements in motor performance within the first five (of 150) trials, and that this “rapid responsiveness” was predictive of skill retention 1 month later. Notably, the extent of rapid responsiveness was not dependent on global cognitive status, as measured by the Montreal Cognitive Assessment (MoCA). Thus, rapid responsiveness appears to be an important variable in longer-term neurorehabilitative efforts with older adults, regardless of their cognitive status

Self-Esteem Among Immigrants Using Mental Health Services

Many immigrants face mental health issues following exposure to war, persecution, and political upheavals from their countries of origin. Post immigration challenges such as shattered social and cultural networks, living conditions, impoverishment, and job procurement contribute to mental health risk factors. This study examines adult immigrants who utilize mental health services at Gateway Community Services. This exploratory research project utilized a cross sectional study and employed quantitative methods. Three participants who self-identified as adult immigrants were recruited using convenience sampling methods. Case managers administered questionnaires to clients to assess their perceived self-esteem. Bi-variable analysis was used to calculate data using Rosenberg’s Perceived Self-Esteem Scale to measure self-esteem. Initial findings show no significant reports of high perceived self-esteem among immigrants who use mental health services

N-mAb: A case study supoorting adoption of integrated continuous bioprocesses

Please click Additional Files below to see the full abstract

Gamma-Ray Burster Counterparts: HST Blue and Ultraviolet Data

The surest solution of the Gamma Ray Burst (GRB) mystery is to find an unambiguous low-energy quiescent counterpart. However, to date no reasonable candidates have been identified in the x-ray, optical, infrared, or radio ranges. The Hubble Space Telescope (HST) has now allowed for the first deep ultraviolet searches for quiescent counterparts. This paper reports on multiepoch ultraviolet searches of five GRB positions with HST. We found no sources with significant ultraviolet excesses, variability, parallax, or proper motion in any of the burst error regions. In particular, we see no sources similar to that proposed as a counterpart to the GRB970228. While this negative result is disappointing, it still has good utility for its strict limits on the no-host-galaxy problem in cosmological models of GRBs. For most cosmological models (with peak luminosity 6X10^50 erg/s), the absolute B magnitude of any possible host galaxy must be fainter than -15.5 to -17.4. These smallest boxes for some of the brightest bursts provide the most critical test, and our limits are a severe problem for all published cosmological burst models.Comment: 15 pages, 2 ps figures, accepted for publication in the Astrophysical Journa

Chronic Experience with Unpredictable Food Availability Promotes Food Reward, Overeating, and Weight Gain in a Novel Animal Model of Food Insecurity

Ubiquitous, easy access to food is thought to promote obesity in the modern environment. However, people coping with food insecurity have limited, unpredictable food access and are also prone to obesity. Causal factors linking food insecurity and obesity are not understood. In this study we describe an animal model to investigate biopsychological impacts of the chronic unpredictability inherent in food insecurity. Female rats were maintained on a \u27secure\u27 schedule of highly predictable 4x/day feedings of uniform size, or an \u27insecure\u27 schedule delivering the same total food over time but frequently unpredictable regarding how much, if any, food would arrive at each scheduled feeding. Subgroups of secure and insecure rats were fed ordinary chow or high-fat/high-sugar (HFHS) chow to identify separate and combined effects of insecurity and diet quality. Insecure chow-fed rats, relative to secure chow-fed rats, were hyperactive and consumed more when provided a palatable liquid diet. Insecure HFHS-fed rats additionally had higher progressive ratio breakpoints for sucrose, increased meal size, and subsequently gained more weight during 8 days of ad libitum HFHS access. Insecurity appeared to maintain a heightened attraction to palatable food that habituated in rats with secure HFHS access. In a second experiment, rats fed ordinary chow on the insecure schedule subsequently gained more weight when provided ad libitum chow, showing that prior insecurity per se promoted short-term weight gain in the absence of HFHS food. We propose this to be a potentially useful animal model for mechanistic research on biopsychological impacts of insecurity, demonstrating that chronic food uncertainty is a factor promoting obesity